Evaluating the Role of Otologic Biomarkers to Differentiate Meniere's Disease and Vestibular Migraine

被引：11

作者：

Naples, James G. ^{[1
]}

Soda, Drew ^{[2
]}

Rahman, Kahlil ^{[3
]}

Ruckenstein, Michael J. ^{[2
]}

Parham, Kourosh ^{[3
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Otolaryngol Head & Neck Surg, 98 Binney St,Shapiro Bldg Ground Floor, Boston, MA 02115 USA

[2] Univ Penn Hlth Syst, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA USA

[3] UCONN Hlth, Div Otolaryngol Head & Neck Surg, Farmington, CT USA

来源：

EAR AND HEARING | 2022年 / 43卷 / 02期

关键词：

Biomarker; Meniere's disease; Vestibular migraine; Vertigo; PRESTIN; HEARING; GUIDELINES; COMMITTEE;

D O I：

10.1097/AUD.0000000000001123

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Objective: To evaluate the role for prestin and otolin-1 as biomarkers for differentiating Meniere's disease (MD) from vestibular migraine (VM). Study Design: It is a cross-sectional, cohort study. Results: There were 19 MD and 11 VM patients. In the 19 MD patients, the mean prestin level was 2.33 ng/ml compared to 0.64 ng/ml in VM patients (p = 0.238). Otolin-1 levels in MD patients were 109.67 pg/ml, while in VM patients, otolin-1 levels were 30.9 pg/ml (p = 0.102). In MD patients, prestin levels were correlated with word recognition scores, being strongest when prestin >2 ng/ml (rho = 0.9; p = 0.019). Conclusions: Prestin and otolin-1 levels differed between MD patients relative to VM patients. The relationship between prestin and word recognition scores in MD suggests that there may be a role for prestin as a marker for inner ear function, but its role in differentiating MD from VM remains to be elucidated.

引用

页码：699 / 702

页数：4