Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease

被引：62

作者：

Iseki, E

Marui, W

Kosaka, K

Akiyama, H

Ueda, K

Iwatsubo, T

机构：

[1] Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Tokyo Inst Psychiat, Setagaya Ku, Tokyo 1560057, Japan

[3] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 258卷 / 02期

关键词：

diffuse lewy body disease; hippocampus; perforant pathway; alpha-synuclein; ubiquitin; immunohistochemistry;

D O I：

10.1016/S0304-3940(98)00856-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the hippocampal pathology in diffuse Lewy body disease (DLBD) using alpha-synuclein immunohistochemistry. Ubiquitin-positive intrahippocampal structures caused by the degeneration of terminal axons of the perforant pathway were observed to be alpha-synuclein immunoreactive. These alpha-synuclein-positive degenerative terminals contained granulo-filamentous or vesiculo-tubular components similar to those of Lewy bodies (LB) immunoelectron microscopically, suggesting that alpha-synuclein may abnormally aggregate into filamentous or membranous cytoskeletal components including neurofilaments and synaptic vesicles in DLBD. A 'dying back' degenerating process due to a blockage of axonal transport may explain why the degenerative terminals and LB share similar alpha-synuclein-positive components, but the origin cells of the perforant pathway contain only a few LB. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：81 / 84

页数：4

共 18 条

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