(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

被引:1
作者
Ihnatenko, Irina [1 ,2 ]
Jones, Peter G. [3 ]
Kunick, Conrad [1 ,2 ]
机构
[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmazeut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany
[2] Tech Univ Carolo Wilhelmina Braunschweig, Ctr Pharmaceut Engn PVZ, Franz Liszt Str 35A, D-38106 Braunschweig, Germany
[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, Hagenring 30, D-38106 Braunschweig, Germany
关键词
oxime ether; benzazepinone; X-ray crystallography; condensation reaction; trypanosomes; POTENT INHIBITORS; PAULLONES;
D O I
10.3390/M1293
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one was prepared by a condensation reaction from 3,4-dihydro-1H-benzo[b]azepin-2,5-dione and O-methylhydroxylamine. The configuration at the C=N double bond was determined by X-ray crystallography.
引用
收藏
页数:5
相关论文
共 50 条
  • [31] Aspects of structural thiohydroxamate chemistry-on a systematic in the 5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione series
    Hartung, Jens
    Bergstrasser, Uwe
    Daniel, Kristina
    Schneiders, Nina
    Svoboda, Ingrid
    Fuess, Hartmut
    TETRAHEDRON, 2009, 65 (12) : 2567 - 2573
  • [32] Photodimerization of (E)-3-(2,6-Difluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one in the Crystalline Solid State
    de Paula, Adriano Farias
    Cesarin-Sobrinho, Dari
    Netto-Ferreira, Jose Carlos
    MOLBANK, 2023, 2023 (02)
  • [33] Crystal Structure of 2-cyclohexyl-5-formyl-6-(4-bromophenyl) Imidazo[2,1-b] [1,3,4] Thiadiazole
    Gowda, K. V. Arjuna
    Kolavi, G. D.
    Khazi, I. M.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2005, 61 : C293 - C294
  • [34] 2-(3,5-Dimethyl-1H-pyrazol-1-yl)thiazolo[4,5-b]pyridine
    Lan, Honghong
    Zheng, Min
    Wang, Ye
    MOLBANK, 2019, 2019 (03)
  • [35] Crystal structure, Hirshfeld surface analysis and PIXEL calculations of the monohydrate of (E)-3-(2-hydroxy-5-methoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one: occurrence of π interactions
    Gomes, Ligia R.
    Low, John N.
    Turner, Alan B.
    Wardell, James L.
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2021, 76 (01): : 27 - 38
  • [36] Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,5,6,7,8-hexahydroquinazolin-2(1H)-ones via three component cyclocondensation
    Phucho, I. T.
    Nongpiur, A.
    Nongrum, R.
    Nongkhlaw, R. L.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2010, 49 (03): : 346 - 350
  • [37] Interaction of cyclic Schiff's bases with 2-methylthiopyrimidine-4,6-dione enol acetate. Synthesis of 5-(2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydro-1- isoquinolyl)-6-hydroxy-2-methylthio-1,4-dihydro-4-pyrimidinones
    Gulyakevich O.V.
    Krasnov K.A.
    Mikhal'chuk A.L.
    Akhrem A.A.
    Chemistry of Heterocyclic Compounds, 2004, 40 (8) : 1070 - 1076
  • [38] PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones
    Zhang, Yanzhi
    Lei, Min
    Xue, Kangsheng
    Sun, Guoxiang
    Zhou, Yang
    Hou, Jinjun
    Long, Huali
    Zhang, Zijia
    Chen, Xubing
    Wu, Wanying
    SYNTHETIC COMMUNICATIONS, 2020, 50 (23) : 3661 - 3668
  • [39] Synthesis and characterisations of some new 2,4-dihydro-[1,2,4]-triazol-3-one derivatives and X-ray crystal structures of 4-(3-phenylallylideneamino)-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]triazol-3-one
    Sancak, Kemal
    Unver, Yasemin
    Kazak, Canan
    Dugdu, Esra
    Arslan, Burcu
    TURKISH JOURNAL OF CHEMISTRY, 2010, 34 (05) : 771 - 780
  • [40] X-ray crystallographic and 13C nuclear magnetic resonance studies of 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-ones derived from ephedrine and pseudoephedrine
    Hitchcock, SR
    Nora, GP
    Casper, DM
    Squire, MD
    Maroules, CD
    Ferrence, GM
    Szczepura, LF
    Standard, JM
    TETRAHEDRON, 2001, 57 (49) : 9789 - 9798