Microglia-mediated synaptic elimination in neuronal development and disease

被引：22

作者：

Whitelaw, Brendan S. ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Sch Med & Dent, Rochester, NY 14642 USA

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2018年 / 119卷 / 01期

关键词：

microglia; synaptic pruning; synaptic plasticity; development; complement; C1q; CX3CR1; P2Y12; ATP; OUTWARD POTASSIUM CURRENTS; VISUAL-CORTEX; OCULAR DOMINANCE; P2Y12; RECEPTOR; IN-VIVO; ACTIVATION; CONNECTIVITY; CHEMOTAXIS; IMPAIRMENT; PLASTICITY;

D O I：

10.1152/jn.00021.2017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has recently become clear that microglia, the immune cells of the central nervous system, are far more active in the healthy brain than previously thought. Microglia facilitate many stages of brain development by shaping neuronal connectivity via synaptic elimination. Dysfunction of these same processes likely underlies a wide range of neurological and neurodevelopmental disorders.

引用

页码：1 / 4

页数：4

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