Rabbit model of subchondral bone bruise and the treatment potential of calcitonin

被引：1
作者：
Hong, Jinsong [1 ]
Wang, Ting [2 ,3 ]
Chen, Zhibin [4 ,5 ]
Pan, Haobo [2 ,3 ]
Pan, Xiaohua [4 ,5 ]
机构：
[1] Guangzhou Orthoped Hosp, Dept Orthoped & Traumatol, Guangzhou, Guangdong, Peoples R China
[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Human Tissue & Organ Degenerat, Shenzhen, Peoples R China
[3] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Key Lab Marine Biomed Mat, Shenzhen, Peoples R China
[4] Southern Med Univ, Baoan Hosp, Dept Orthoped & Traumatol, Shenzhen 518100, Peoples R China
[5] Shenzhen Eighth Peoples Hosp, Shenzhen 518100, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2017年 / 9卷 / 12期
关键词：
Rabbits model; subchondral bone bruise; magnetic resonance imaging; calcitonin; ACUTELY INJURED KNEE; FAST SPIN-ECHO; STIR IMAGES; MR; CONTUSIONS; CARTILAGE; LESIONS; JOINT;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: This study characterized a novel rabbit model of subchondral bone bruise and investigated the intervening effect of calcitonin. Methods: Bone bruise was implemented via controlled free-fall counterpoise on the medial tibial subchondral bone of 5-month-old New Zealand rabbits, with 3, 2.5, or 2 Joules of energy. Subsequent subchondral bone bruise was characterized via magnetic resonance imaging, micro computed tomography, and histology. Calcitonin was administered for 3 weeks, and the changes in subchondral bone were characterized. Results: The severity of subchondral bone bruise lesions correlated with the energy applied. The lesions involved trabecular separation and reduced trabecular number, with bone marrow edema and trabecular micro-fracture. With calcitonin treatment, subchondral bone marrow edema subsided and trabecular ultrastructure repaired. Conclusion: Free fall counterpoise is a promising method to establish a subchondral bone bruise model in rabbits. Calcitonin injection is a potential treatment for subchondral bone bruise lesions.
引用
收藏
页码：5603 / 5610
页数：8
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