Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis

被引：30

作者：

Esposito, Carla ^{[1
]}

Pethoukov, Maxim V. ^{[2
]}

Svergun, Dmitri I. ^{[2
]}

Ruggiero, Alessia ^{[1
]}

Pedone, Carlo ^{[1
,3
]}

Pedone, Emilia ^{[1
]}

Berisio, Rita ^{[1
]}

机构：

[1] Univ Naples Federico II, Ist Biostrutture Bioimmagini, CNR, I-80134 Naples, Italy

[2] DESY, European Mol Biol Lab, D-22603 Hamburg, Germany

[3] Univ Naples Federico II, Dipartimento Sci Biol, Sez Biostrutture, I-80134 Naples, Italy

来源：

JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 13期

关键词：

D O I：

10.1128/JB.01988-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.

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页码：4749 / 4753

页数：5

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