Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis

被引：30
作者：
Esposito, Carla [1 ]
Pethoukov, Maxim V. [2 ]
Svergun, Dmitri I. [2 ]
Ruggiero, Alessia [1 ]
Pedone, Carlo [1 ,3 ]
Pedone, Emilia [1 ]
Berisio, Rita [1 ]
机构：
[1] Univ Naples Federico II, Ist Biostrutture Bioimmagini, CNR, I-80134 Naples, Italy
[2] DESY, European Mol Biol Lab, D-22603 Hamburg, Germany
[3] Univ Naples Federico II, Dipartimento Sci Biol, Sez Biostrutture, I-80134 Naples, Italy
来源：
JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 13期
关键词：
D O I：
10.1128/JB.01988-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.
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收藏
页码：4749 / 4753
页数：5
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