Pediatric Community-Acquired Bone and Joint Staphylococcus Aureus Infections In Europe Severe Infections are Associated to Panton-Valentine Leucocidin Presence

被引：12

作者：

Gijon, Manuel ^{[1
]}

Bellusci, Marcello ^{[1
]}

Petraitiene, Birute ^{[2
]}

Noguera-Julian, Antoni ^{[3
,4
,5
,6
]}

Glikman, Daniel ^{[7
]}

Saavedra-Lozano, Jesus ^{[8
]}

Neth, Olaf ^{[9
]}

Daskalaki, Maria ^{[10
]}

Zilinskaite, Virginija ^{[11
]}

Kaiser-Labusch, Petra ^{[12
]}

Prieto, Luis ^{[13
]}

Rojo, Pablo ^{[1
,14
]}

机构：

[1] Hosp 12 Octubre, Pediat Infect Dis Dept, Madrid, Spain

[2] Lithuanian Univ Hlth Sci, Hosp Lithuanian Univ Hlth Sci Kauno Klin, Dept Pediat, Kaunas, Lithuania

[3] Hosp St Joan Deu, Inst Recerca Pediat, Serv Pediat,Unitat Infecc, Malalt Infeccioses & Resposta Inflamatoria Sistem, Barcelona, Spain

[4] Univ Barcelona, Dept Pediat, Barcelona, Spain

[5] CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain

[6] RITIP, Red Invest Translac Infectol Pediat, Madrid, Spain

[7] Bar Ilan Univ, Azrieli Fac Med Galilee, Safed, Israel

[8] Univ Complutense Madrid, Gregorio Maranon Hospital, Pediat Infect Dis Unit, Madrid, Spain

[9] Hosp Univ Virgen Rocio, Paediat Infect Dis, Seville, Spain

[10] Penteli Childrens Hosp Athens, Clin Microbiol, Athens, Greece

[11] Vilnius Univ, Fac Med, Inst Clin Med, Clin Childrens Dis, Vilnius, Lithuania

[12] Prof Hess Childrens Hosp, Bremen, Germany

[13] Hosp Getafe, Pediat Infect Dis, Getafe, Spain

[14] Univ Complutense Madrid, Madrid, Spain

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2020年 / 39卷 / 06期

关键词：

aureus; children; osteomyelitis; arthritis; PVL; METHICILLIN-RESISTANT; MUSCULOSKELETAL INFECTIONS; ACUTE OSTEOMYELITIS; LEUKOCIDIN; CHILDREN; MANAGEMENT; DISEASE; GENES;

D O I：

10.1097/INF.0000000000002640

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.

引用

页码：E73 / E76

页数：4

共 19 条

[1] Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children [J].

Bocchini, CE ;

Hulten, KG ;

Mason, EO ;

Gonzalez, BE ;

Hammerman, WA ;

Kaplan, SL .

PEDIATRICS, 2006, 117 (02) :433-440

[2] Epidemiology and Management of Acute, Uncomplicated Septic Arthritis and Osteomyelitis Spanish Multicenter Study [J].

Calvo, Cristina ;

Nunez, Esmeralda ;

Camacho, Marisol ;

Clemente, Daniel ;

Fernandez-Cooke, Elisa ;

Alcobendas, Rosa ;

Mayol, Luis ;

Soler-Palacin, Pere ;

Oscoz, Miren ;

Saavedra-Lozano, Jesus .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2016, 35 (12) :1288-1293

[3] Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK [J].

Cunnington, A. ;

Brick, T. ;

Cooper, M. ;

Danin, J. ;

Hunt, D. ;

Jeanes, A. ;

Kearns, A. M. ;

Nolan, M. ;

Lyall, H. .

JOURNAL OF INFECTION, 2009, 59 (01) :28-36

[4] Panton-Valentine leukocidin-positive Staphylococcus aureus skin and soft tissue infections among children in an emergency department in Madrid, Spain [J].

Daskalaki, M. ;

Rojo, P. ;

Marin-Ferrer, M. ;

Barrios, M. ;

Otero, J. R. ;

Chaves, F. .

CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (01) :74-77

[5] Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus [J].

Dohin, Bruno ;

Gillet, Yves ;

Kohler, Remi ;

Lina, Gerard ;

Vandenesch, Francois ;

Vanhems, Philippe ;

Floret, Daniel ;

Etienne, Jerome .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2007, 26 (11) :1042-1048

[6] Factors associated with severity in invasive community-acquired Staphylococcus aureus infections in children: a prospective European multicentre study [J].

Gijon, M. ;

Bellusci, M. ;

Petraitiene, B. ;

Noguera-Julian, A. ;

Zilinskaite, V. ;

Moreno, P. Sanchez ;

Saavedra-Lozano, J. ;

Glikman, D. ;

Daskalaki, M. ;

Kaiser-Labusch, P. ;

Falup-Pecurariu, O. ;

Montagnani, C. ;

Prieto, L. ;

Gene, A. ;

Trumpulyte, G. ;

Kulecnikova, I. ;

Lepe, J. A. ;

Cercenado, E. ;

Kudinsky, R. ;

Makri, A. ;

Huppertz, H. I. ;

Bleotu, L. ;

Cocchi, P. ;

Garcia-Hierro, P. ;

Vitkauskiene, A. ;

Fortuny, C. ;

Zukovskaja, V. ;

Neth, O. ;

Santos, M. ;

Rokney, A. ;

Petra, M. ;

Lixandru, R. ;

Galli, L. ;

Guillen, S. ;

Chaves, F. ;

Conejo, P. Rojo .

CLINICAL MICROBIOLOGY AND INFECTION, 2016, 22 (07) :643.e1-643.e6

[7] Pragmatic management of Panton-Valentine leukocidin-associated staphylococcal diseases [J].

Gillet, Y. ;

Dumitrescu, O. ;

Tristan, A. ;

Dauwalder, O. ;

Javouhey, E. ;

Floret, D. ;

Vandenesch, F. ;

Etienne, J. ;

Lina, G. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 38 (06) :457-464

[8] Severe staphylococcal sepsis in adolescents in the era of community-acquired methicillin-resistant Staphylococcus aureus [J].

Gonzalez, BE ;

Martinez-Aguilar, G ;

Hulten, KG ;

Hammerman, WA ;

Coss-Bu, J ;

Avalos-Mishaan, A ;

Mason, EO ;

Kaplan, SL .

PEDIATRICS, 2005, 115 (03) :642-648

[9] Staphylococcus aureus isolates carrying panton-valentine leucocidin genes in England and Wales:: Frequency, characterization, and association with clinical disease [J].

Holmes, A ;

Ganner, M ;

McGuane, S ;

Pitt, TL ;

Cookson, BD ;

Kearns, AM .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (05) :2384-2390

[10] Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions [J].

Kavanagh, Nicola ;

Ryan, Emily J. ;

Widaa, Amro ;

Sexton, Gillian ;

Fennell, Jerome ;

O'Rourke, Sadhbh ;

Cahill, Kevin C. ;

Kearney, Cathal J. ;

O'Brien, Fergal J. ;

Kerrigan, Steven W. .

CLINICAL MICROBIOLOGY REVIEWS, 2018, 31 (02)

← 1 2 →