Biological effects of TrkA and TrkB receptor signaling in neuroblastoma

被引：98

作者：

Schramm, A

Schulte, JH

Astrahantseff, K

Apostolov, O

van Limpt, V

Sieverts, H

Kuhfittig-Kulle, S

Pfeiffer, P

Versteeg, R

Eggert, A

机构：

[1] Univ Childrens Hosp Essen, Div Hematol Oncol & Endocrinol, D-45122 Essen, Germany

[2] Univ Amsterdam, Acad Med Ctr, Dept Human Genet, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Childrens Hosp, Div Hematol Oncol, Heidelberg, Germany

[4] Univ Essen Gesamthsch, Dept Biol, Essen, Germany

来源：

CANCER LETTERS | 2005年 / 228卷 / 1-2期

关键词：

neuroblastoma; Trk receptors; neurotrophins; expression profiling; microarrays;

D O I：

10.1016/j.canlet.2005.02.051

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells. Expression of Trk receptors also plays an important role in the biology and clinical behavior of neuroblastomas. High expression of TrkA is present in neuroblastomas with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：143 / 153

页数：11

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