Antiretroviral Adherence and the Nature of HIV-Associated Verbal Memory Impairment

被引:16
|
作者
Wright, Matthew J. [1 ]
Woo, Ellen
Foley, Jessica [3 ,4 ]
Ettenhofer, Mark L. [5 ]
Cottingham, Maria E. [1 ]
Gooding, Amanda L. [6 ]
Jang, Jiah [7 ]
Kim, Michelle S. [8 ]
Castellon, Steve A. [2 ,7 ]
Miller, Eric N. [2 ,9 ]
Hinkin, Charles H. [2 ,7 ]
机构
[1] Harbor UCLA Med Ctr, Psychol Div, Dept Psychiat, Torrance, CA 90509 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] VA Boston Healthcare Syst, Dept Psychol, Brockton, MA USA
[4] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
[5] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA
[6] Fordham Univ, Dept Psychol, Bronx, NY 10458 USA
[7] VA Greater Los Angeles Healthcare Syst, Dept Psychol, Los Angeles, CA USA
[8] Fuller Theol Seminary, Dept Psychol, Pasadena, CA 91101 USA
[9] Univ Calif Los Angeles, Dept Psychol, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA
关键词
MULTICENTER AIDS COHORT; NEUROCOGNITIVE IMPAIRMENT; RETRIEVAL DEFICITS; DEMENTIA COMPLEX; THERAPY; INFECTION; PERFORMANCE; INDIVIDUALS; HIV/AIDS; DYSFUNCTION;
D O I
10.1176/appi.neuropsych.23.3.324
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors investigated the relationship between antiretroviral adherence and HIV-associated verbal memory impairment. HIV-positive participants demonstrated poorer verbal memory than HIV-negative participants. Both good (>= 90%) and poor (<90%) adherers displayed encoding deficits as compared with controls, but only poor adherers exhibited retrieval deficits. Encoding deficits primarily accounted for reduced delayed recall in good adherers, but both encoding and retrieval deficits accounted for reduced delayed recall in poor adherers. The retrieval difference between the adherence groups might be explained by a neuroprotective effect of good antiretroviral adherence or preexisting HIV-related retrieval deficits that result in poorer adherence. (The Journal of Neuropsychiatry and Clinical Neurosciences 2011; 23:324-331)
引用
收藏
页码:324 / 331
页数:8
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