Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii

被引：26

作者：

Fouotsa, Hugues ^{[1
,2
]}

Lannang, Alain Meli ^{[2
,3
]}

Dzoyem, Jean Paul ^{[4
]}

Tatsimo, Simplice J. N. ^{[3
]}

Neumann, Beate ^{[5
]}

Mbazoa, Celine Djama ^{[1
]}

Razakarivony, Andrianambinina Andriamarolahy ^{[2
]}

Nkengfack, Augustin Ephrem ^{[1
]}

Eloff, Jacobus N. ^{[6
]}

Sewald, Norbert ^{[2
]}

机构：

[1] Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon

[2] Univ Bielefeld, Dept Chem Organ & Bioorgan Chem, D-33615 Bielefeld, Germany

[3] Univ Maroua, Dept Chem, Higher Teachers Training Coll, Maroua, Cameroon

[4] Univ Dschang, Dept Biochem, Fac Sci, Dschang, Cameroon

[5] Univ Bielefeld, Dept Chem Inorgan & Struct Chem, D-33615 Bielefeld, Germany

[6] Univ Pretoria, Fac Vet Sci, Dept Paraclin Sci, Phytomed Programme, ZA-0002 Pretoria, South Africa

来源：

PLANTA MEDICA | 2015年 / 81卷 / 07期

关键词：

Garcinia smeathmannii; Guttiferae; xanthone; benzophenone; antibacterial; antioxidant; PRENYLATED XANTHONES; BARK; MANGOSTANA; OLIVER;

D O I：

10.1055/s-0035-1545841

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2DNMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent antibacterial activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 mu g/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.

引用

页码：594 / 599

页数：6

共 31 条

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