Estrogen intervention in microvascular morphology and choline acetyltransferase expression in rat hippocampal neurons in chronic cerebral ischemia

被引：1

作者：

Yang, Zhenjun ^{[1
]}

Yan, Hongwei ^{[2
]}

Zhang, Guomin ^{[2
]}

Chen, Zhihong ^{[1
]}

Xue, Jingfeng ^{[1
]}

机构：

[1] Chengde Med Coll, Dept Anat, Chengde 067000, Hebei Province, Peoples R China

[2] Chengde Med Coll, Affiliated Hosp, Chengde 067000, Hebei Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 17期

关键词：

estrogen; chronic cerebral ischemia; hippocampus; microvasculature; Bcl-2; Bax; choline acetyltransferase; neural regeneration; BCL-2; APOPTOSIS; ESTRADIOL; RELEASE; DISEASE; BETA;

D O I：

10.3969/j.issn.1673-5374.2011.17.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We observed dynamic changes in microvessels and a protective effect of estrogen on chronic cerebral ischemia ovariectomized rat models established through permanent occlusion of bilateral carotid arteries at 7, 14 and 21 days. The results revealed that estrogen improved microvasculature in the hippocampus of chronic cerebral ischemic rats, upregulated Bcl-2 protein expression, downregulated Bax protein expression, increased choline acetyltransferase expression in hippocampal cholinergic neurons, and suppressed hippocampal neuronal apoptosis. These findings indicate that estrogen can protect hippocampal neurons in rats with chronic cerebral ischemia.

引用

页码：1285 / 1290

页数：6

共 50 条

[1] Estrogen intervention in microvascular morphology and choline acetyltransferase expression in rat hippocampal neurons in chronic cerebral ischemia
Zhenjun Yang1
NeuralRegenerationResearch, 2011, 6 (17) : 1285 - 1290
[2] ENHANCEMENT OF CHOLINE-ACETYLTRANSFERASE ACTIVITY IN COCULTURE OF RAT SEPTAL AND HIPPOCAMPAL-NEURONS
AKANEYA, Y
TAKAHASHI, M
TSUKUI, H
HATANAKA, H
BRAIN RESEARCH, 1994, 642 (1-2) : 38 - 46
[3] Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat
Kanayama, H
Yasuhara, O
Matsuo, A
Tooyama, I
Aimi, Y
Bellier, JP
Nagy, JI
Fukui, K
Kimura, H
NEUROSCIENCE, 2003, 118 (01) : 243 - 251
[4] IS THERE A LINK BETWEEN CHOLINE ACETYLTRANSFERASE-CONTAINING NEURONS AND BUTYRYLCHOLINESTERASE IN RAT CEREBRAL-CORTEX
HENDERSON, Z
TRENDS IN NEUROSCIENCES, 1986, 9 (01) : 20 - 20
[5] CHOLINERGIC NEURONS IN THE RAT CEREBRAL-CORTEX DEMONSTRATED BY IMMUNOHISTOCHEMICAL LOCALIZATION OF CHOLINE-ACETYLTRANSFERASE
ECKENSTEIN, F
THOENEN, H
NEUROSCIENCE LETTERS, 1983, 36 (03) : 211 - 215
[6] Tamoxifen enhances choline acetyltransferase mRNA expression in rat basal forebrain cholinergic neurons
McMillan, PJ
LeMaster, AM
Dorsa, DM
MOLECULAR BRAIN RESEARCH, 2002, 103 (1-2): : 140 - 145
[7] Ocimum sanctum Linn. stimulate the expression of choline acetyltransferase on the human cerebral microvascular endothelial cells
Kusindarta, Dwi Liliek
Wihadmadyatami, Hevi
Haryanto, Aris
VETERINARY WORLD, 2016, 9 (12) : 1348 - 1354
[8] The neuroprotective effect of lentivirus on choline acetyltransferase mRNA expression of hippocampal neurons and behavior in senile dementia rats
Yan, S.
Cao, J.
Zhang, H.
Bai, J.
BRAIN PATHOLOGY, 2014, 24 : 50 - 50
[9] EFFECTS OF POSTNATAL HYPOXIA ISCHEMIA ON CHOLINERGIC NEURONS IN THE DEVELOPING RAT FOREBRAIN - CHOLINE-ACETYLTRANSFERASE IMMUNOCYTOCHEMISTRY
JOHNSTON, MV
HUDSON, C
DEVELOPMENTAL BRAIN RESEARCH, 1987, 34 (01): : 41 - 50
[10] Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion
Liu, Yajun
Wang, Paulus S.
Xie, Dongping
Liu, Kejing
Chen, Lianbi
CHINESE JOURNAL OF PHYSIOLOGY, 2006, 49 (05): : 244 - 250

← 1 2 3 4 5 →