Progress and Challenges towards Point-of-Care Diagnostic Development for Dengue

被引：41

作者：

Pang, Junxiong ^{[1
,2
]}

Chia, Po Ying ^{[1
]}

Lye, David C. ^{[1
,3
,4
]}

Leo, Yee Sin ^{[1
,2
,3
,4
]}

机构：

[1] Tan Tock Seng Hosp, Inst Infect Dis & Epidemiol, Singapore, Singapore

[2] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[3] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2017年 / 55卷 / 12期

基金：

英国医学研究理事会;

关键词：

dengue fever; biotechnology; clinical diagnosis; diagnostics tools; flavivirus; neutralizing antibodies; point-of-care test; serology; viral clearance; REVERSE-TRANSCRIPTASE PCR; TIME RT-PCR; NS1; ANTIGEN; RAPID DETECTION; CHANGING EPIDEMIOLOGY; CHIKUNGUNYA-VIRUS; PAN-DENGUE; MULTIPLEX; ASSAY; INFECTION;

D O I：

10.1128/JCM.00707-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue detection strategies involve viral RNA, antigen, and/or antibody detection. Each strategy has its advantages and disadvantages. Optimal, user-friendly, rapid diagnostic tests based on immunochromatographic assays are pragmatic point-ofcare tests (POCTs) in regions where dengue is endemic where there are limited laboratory capabilities and optimal storage conditions. Increasingly, there is a greater public health significance for a multiplexing assay that differentiates dengue from Zika or pathogens with similar clinical presentations. Although there have been many assay/platform developments toward POCTs, independent validation and implementation remain very limited. This review highlights the current key progress and challenges toward the development of a dengue POCT.

引用

页码：3339 / 3349

页数：11

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