One biocatalyst - Many applications: The use of Candida antarctica B-lipase in organic synthesis

被引：589

作者：

Anderson, EM ^{[1
]}

Karin, M ^{[1
]}

Kirk, O ^{[1
]}

机构：

[1] Novo Nordisk AS, DK-2880 Bagsvaerd, Denmark

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 1998年 / 16卷 / 03期

关键词：

Candida antarctica B-lipase; predicted specificity; regio-selectivity; enantio-selectivity; esters; amides; peroxycarboxylic acids;

D O I：

10.3109/10242429809003198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of the B-component lipase from the yeast Candida antarctica in organic synthesis is reviewed. This enzyme has been found to be a particularly efficient and robust lipase catalyzing a surprising diversity of reactions including many different regio- and enantio-selective syntheses. Furthermore, the C. antarctica B-lipase is an example of an enzyme for which its specificity has been predicted based on the crystal structure and modeling of the active site region. This prediction is compared to experimental observations and a very close correlation is found.

引用

页码：181 / 204

页数：24

共 152 条

[1] ENZYME CATALYZED PREPARATION OF 6-O-ACYLGLUCOPYRANOSIDES [J].