Smaller fetal thymuses in pre-eclampsia: a prospective cross-sectional study

被引:37
作者
Mohamed, N. [1 ]
Eviston, D. P. [2 ]
Quinton, A. E. [1 ]
Benzie, R. J. [1 ]
Kirby, A. C. [3 ]
Peek, M. J. [1 ]
Nanan, R. K. [2 ]
机构
[1] Univ Sydney, Sydney Med Sch Nepean, Discipline Obstet & Gynaecol, Kingswood, NSW 2751, Australia
[2] Univ Sydney, Sydney Med Sch Nepean, Discipline Paediat, Kingswood, NSW 2751, Australia
[3] NHMRC Clin Trials Ctr, Sydney, NSW, Australia
关键词
fetal thymus; gestational age; pre-eclampsia; PRETERM PREMATURE RUPTURE; THYMIC INVOLUTION; BIRTH-WEIGHT; SIZE; CHORIOAMNIONITIS; PREGNANCY; INFANTS; MARKER; MALNUTRITION; INFECTION;
D O I
10.1002/uog.8953
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Objective To determine whether the thymus is smaller in fetuses of pre-eclamptic mothers than in those of normal controls. Methods This was a cross-sectional, prospective, comparative study of sonographically determined fetal thymus measurements in 39 pregnancies with pre-eclampsia and 70 healthy pregnancies. Results Both the diameter and the perimeter of the fetal thymus were smaller in pregnancies with pre-eclampsia than in healthy controls. The means of the thymus diameters were 28.6 +/- 5.9 and 32.9 +/- 4.5 mm and of thymus perimeters 80.9 +/- 16.5 and 93.1 +/- 16.6 mm for pre-eclamptic and healthy pregnancies, respectively (P < 0.001). General linear models showed that smaller fetal thymuses in pre-eclampsia were independent of gestational age, estimated fetal weight, small for gestational age status and antenatal steroid use. Conclusions Pre-eclampsia is associated with smaller fetal thymuses. Copyright (C) 2011 ISUOG. Published by John Wiley & Sons, Ltd.
引用
收藏
页码:410 / 415
页数:6
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