A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions

被引：32

作者：

Belhani, Billel ^{[1
]}

Berredjem, Malika ^{[1
]}

Le Borgne, Marc ^{[2
,3
,4
]}

Bouaziz, Zouhair ^{[2
,3
,4
]}

Lebreton, Jacques ^{[5
]}

Aouf, Nour-Eddine ^{[1
]}

机构：

[1] BadjiMokhtar Annaba Univ, Synth Biomol & Mol Modelling Grp, Lab Appl Organ Chem, Sci Fac,Chem Dept, Annaba 23000, Algeria

[2] Univ Lyon 1, Fac Pharm, F-69373 Lyon 8, France

[3] Univ Lyon 1, ISPB, EA Biomol Canc & Chimioresistances 446, SFR Sante Lyon Est,CNRS UMS3453, F-69373 Lyon 8, France

[4] Univ Lyon 1, INSERM US7, F-69373 Lyon 8, France

[5] Univ Nantes, UMR CNRS Chim & Interdisciplinar Synth Anal 6230, UFR Sci & Techn, F-44322 Nantes 3, France

来源：

RSC ADVANCES | 2015年 / 5卷 / 49期

关键词：

AMINO PHOSPHONATES; MULTICOMPONENT REACTIONS; ACID; INHIBITORS; DERIVATIVES; CHEMISTRY;

D O I：

10.1039/c5ra03473f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and convenient one-pot synthesis of novel alpha-sulfamidophosphonates is described via a three-component reaction. This reaction was carried out through a three component condensation reaction of sulfonamide, an aromatic aldehyde and triethylphosphite under conventional/ultrasonic techniques, catalyst-free and solvent-free conditions. This methodology was established with many advantages, including mild reaction conditions, short reaction times, good yields, simple work-up procedures, and environmental friendliness.

引用

页码：39324 / 39329

页数：6

共 43 条

[1] RENIN INHIBITORS - SYNTHESIS OF TRANSITION-STATE ANALOG INHIBITORS CONTAINING PHOSPHORUS-ACID DERIVATIVES AT THE SCISSILE BOND [J].