CD33-related siglecs as potential modulators of inflammatory responses

被引：83

作者：

Crocker, Paul R. ^{[1
]}

McMillan, Sarah J. ^{[1
]}

Richards, Hannah E. ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Coll Life Sci, Div Cell Signaling & Immunol, Dundee DD1 5EH, Scotland

来源：

GLYCOBIOLOGY OF THE IMMUNE RESPONSE | 2012年 / 1253卷

关键词：

immunoglobulin superfamily; inhibitory receptors; innate immunity; siglecs; sialic acid; CD33; IMMUNOGLOBULIN-LIKE LECTINS; NATURAL-KILLER-CELLS; INHIBITORY MOTIF; MAST-CELLS; T-CELLS; RECEPTOR; BINDING; MACROPHAGES; IDENTIFICATION; EOSINOPHILS;

D O I：

10.1111/j.1749-6632.2011.06449.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immune system must be tightly regulated to prevent unwanted tissue damage caused by exaggerated immune and inflammatory reactions. Inhibitory and activating immune receptors play a crucial role in this function via phosphotyrosine-dependent signaling pathways. A significant body of evidence has accumulated suggesting that the siglec family of sialic acid binding Ig-like lectins makes an important contribution to this immunoregulation. The CD33-related siglecs are a distinct subset of inhibitory and activating receptors, expressed primarily on leukocytes in a cell type-specific manner. Here, we critically assess the in vitro and in vivo evidence on the functional role for CD33-related siglecs in modulation of inflammatory and immune responses.

引用

页码：102 / 111

页数：10

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