Polysorbate 80 coated poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) micelles for paclitaxel delivery

被引：62

作者：

Wang, YuJun ^{[1
]}

Wang, Cheng ^{[1
]}

Gong, ChangYang ^{[1
]}

Wang, YingJing ^{[1
]}

Guo, Gang ^{[1
]}

Luo, Feng ^{[1
]}

Qian, ZhiYong ^{[1
]}

机构：

[1] Sichuan Univ, State Key Lab Biotherapy, W China Hosp, W China Med Sch, Chengdu 610041, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 434卷 / 1-2期

关键词：

Poly (epsilon-caprolactone)-poly (ethyleneglycol)-poly (epsilon-caprolactone); Paclitaxel; Micelles; Polysorbate; 80; Blood-brain barrier; BLOOD-BRAIN-BARRIER; SULFATE CHITOSAN MICELLES; CELL LUNG-CANCER; IN-VITRO; POLYMERIC MICELLES; MEDIATED TRANSPORT; COPOLYMER MICELLES; CONTROLLED-RELEASE; TARGETED DELIVERY; BLOCK-COPOLYMER;

D O I：

10.1016/j.ijpharm.2012.05.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this article, polysorbate 80 coated poly (epsilon-caprolactone)-poly (ethylene glycol)-poly (epsilon-caprolactone) (PCEC) micelles were successfully prepared for paclitaxel (PTX) delivery. The particle size distribution, morphology, drug loading, encapsulation efficiency and sustained release profile of the micelles were studied in detail. The safety of the micelle formulation was evaluated by MTT assay on HEK293 cells. And the encapsulated PTX in the micelles remained potent antitumor effect on C6 glioma cells. The pharmacokinetic study showed that the PCEC micelles coated with polysorbate 80 altered the biodistribution pattern and increased PTX concentration in the brain significantly compared to the uncoated micelles and the free drug after intravenous injection. The results indicated that polysorbate 80 coated PCEC micelles might be a candidate for PTX delivery for brain tumor chemotherapy. (c) 2012 Elsevier B. V. All rights reserved.

引用

页码：1 / 8

页数：8

共 68 条

[1] Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles [J].