Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implications

被引：162
作者：
Carlsson, A
Hansson, LO
Waters, N
Carlsson, ML
机构：
来源：
LIFE SCIENCES | 1997年 / 61卷 / 02期
关键词：
neurotransmitters; glutamate deficiency hypothesis of schizophrenia; gender; psychotogenic neurocircuitries; thalamus; schizophrenia;
D O I：
10.1016/S0024-3205(97)00228-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The dopamine hypothesis has dominated schizophrenia research for decades but is now yielding to a more diversified view, where the interaction of several neurotransmitters in complex circuitries is under scrutiny. Especially, glutamatergic and serotonergic mechanisms are attracting attention. However, the role of dopamine also needs further exploration and may still turn out to have novel therapeutic applications. III the present minireview an attempt is made to integrate preclinical and clinical data on neurotransmitter aberrations in schizophrenia and to discuss their therapeutic implications.
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页码：75 / 94
页数：20
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