Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products

被引:107
作者
Cunningham, Charles H. [1 ,2 ]
Chen, Albert P. [3 ]
Lustig, Michael [4 ]
Hargreaves, Brian A. [5 ]
Lupo, Janine [3 ]
Xu, Duan [3 ]
Kurhanewicz, John [3 ]
Hurd, Ralph E. [6 ]
Pauly, John M. [4 ]
Nelson, Sarah J. [3 ]
Vigneron, Daniel B. [3 ]
机构
[1] Dept Med Biophys, Toronto, ON M4N 3M5, Canada
[2] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada
[3] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
[4] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA
[5] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
[6] GE Healthcare Technol, Menlo Pk, CA USA
关键词
C-13; hyperpolarized; lactate; spectral-spatial; metabolism;
D O I
10.1016/j.jmr.2008.03.012
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Dynamic nuclear polarization and dissolution of a C-13-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 x 32 x 16 voxels every 3.5 s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:139 / 146
页数:8
相关论文
共 15 条
  • [1] Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR
    Ardenkjaer-Larsen, JH
    Fridlund, B
    Gram, A
    Hansson, G
    Hansson, L
    Lerche, MH
    Servin, R
    Thaning, M
    Golman, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) : 10158 - 10163
  • [2] INTERLEAVED ECHO-PLANAR IMAGING ON A STANDARD MRI SYSTEM
    BUTTS, K
    RIEDERER, SJ
    EHMAN, RL
    THOMPSON, RM
    JACK, CR
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1994, 31 (01) : 67 - 72
  • [3] Hyperpolarized c-13 spectroscopic imaging of the TRAMP mouse at 3T - Initial experience
    Chen, Albert P.
    Albers, Mark J.
    Cunningham, Charles H.
    Kohler, Susan J.
    Yen, Yi-Fen
    Hurd, Ralph E.
    Tropp, James
    Bok, Robert
    Pauly, John M.
    Nelson, Sarah J.
    Kurhanewicz, John
    Vigneron, Daniel B.
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2007, 58 (06) : 1099 - 1106
  • [4] Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C
    Cunningham, Charles H.
    Chen, Albert P.
    Albers, Mark J.
    Kurhanewicz, John
    Hurd, Ralph E.
    Yen, Yi-Fen
    Pauly, John M.
    Nelson, Sarah J.
    Vigneron, Daniel B.
    [J]. JOURNAL OF MAGNETIC RESONANCE, 2007, 187 (02) : 357 - 362
  • [5] Molecular imaging with endogenous substances
    Golman, K
    Ardenær-Larsen, JH
    Petersson, JS
    Månsson, S
    Leunbach, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) : 10435 - 10439
  • [6] Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis
    Golman, Klaes
    in't Zandt, Rene
    Lerche, Mathilde
    Pehrson, Rikard
    Ardenkjaer-Larsen, Jan Henrik
    [J]. CANCER RESEARCH, 2006, 66 (22) : 10855 - 10860
  • [7] Metabolic imaging and other applications of hyperpolarized 13C
    Golman, Klaes
    Petersson, J. Stefan
    [J]. ACADEMIC RADIOLOGY, 2006, 13 (08) : 932 - 942
  • [8] Real-time metabolic imaging
    Golman, Klaes
    in't Zandt, Rene
    Thaning, Mikkel
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) : 11270 - 11275
  • [9] In vivo 13carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate
    Kohler, S. J.
    Yen, Y.
    Wolber, J.
    Chen, A. P.
    Albers, M. J.
    Bok, R.
    Zhang, V.
    Tropp, J.
    Nelson, S.
    Vigneron, D. B.
    Kurhanewicz, J.
    Hurd, R. E.
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2007, 58 (01) : 65 - 69
  • [10] SIMULTANEOUS SPATIAL AND SPECTRAL SELECTIVE EXCITATION
    MEYER, CH
    PAULY, JM
    MACOVSKI, A
    NISHIMURA, DG
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1990, 15 (02) : 287 - 304