Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products

被引：110

作者：

Cunningham, Charles H. ^{[1
,2
]}

Chen, Albert P. ^{[3
]}

Lustig, Michael ^{[4
]}

Hargreaves, Brian A. ^{[5
]}

Lupo, Janine ^{[3
]}

Xu, Duan ^{[3
]}

Kurhanewicz, John ^{[3
]}

Hurd, Ralph E. ^{[6
]}

Pauly, John M. ^{[4
]}

Nelson, Sarah J. ^{[3
]}

Vigneron, Daniel B. ^{[3
]}

机构：

[1] Dept Med Biophys, Toronto, ON M4N 3M5, Canada

[2] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[3] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[4] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[6] GE Healthcare Technol, Menlo Pk, CA USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2008年 / 193卷 / 01期

关键词：

C-13; hyperpolarized; lactate; spectral-spatial; metabolism;

D O I：

10.1016/j.jmr.2008.03.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dynamic nuclear polarization and dissolution of a C-13-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 x 32 x 16 voxels every 3.5 s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：139 / 146

页数：8

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