A Case of Myeloma with Hypercalcemia Caused by High Serum Concentrations of both Parathyroid Hormone-related Peptide (PTHrP) and Macrophage Inflammatory Protein-1α (MIP-1α)

被引：6

作者：

Shimizu, Hiroaki ^{[1
]}

Monden, Tsuyoshi ^{[1
]}

Tomotsune, Takanori ^{[1
]}

Nakatani, Yuki ^{[2
]}

Domeki, Nozomi ^{[1
]}

Matsumura, Mihoko ^{[3
]}

Jojima, Teruo ^{[1
]}

Kawagoe, Yoshiaki ^{[1
]}

Kasai, Kikuo ^{[1
]}

机构：

[1] Dokkyo Med Univ, Dept Endocrinol & Metab, Mibu, Tochigi, Japan

[2] Dokkyo Med Univ, Dept Diabet & Endocrinol, Nikko Med Ctr, Mibu, Tochigi, Japan

[3] Tochigi Med Assoc Shiobara Onsen Hosp, Dept Internal Med, Mibu, Tochigi, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 24期

关键词：

humoral hypercalcemia of malignancy; local osteolytic hypercalcemia; macrophage inflammatory protein-1 alpha; parathyroid hormone-related peptide; MULTIPLE-MYELOMA; PROTEIN (MIP)-1-ALPHA; EXPRESSION; MIP-1-BETA; BINDING; LESIONS; CELLS;

D O I：

10.2169/internalmedicine.50.6096

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 62-year-old woman was admitted with dry mouth, general fatigue, and severe back pain. Biochemistry examination showed extreme hypercalcemia (21.2 mg/dL). Bone marrow examination was negative, but needle biopsy of a metastatic lung tumor revealed abnormal plasma cells; thus, multiple myeloma stage III-A was finally diagnosed. Serum concentrations of both parathyroid hormone-related peptide (PTHrP) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) were markedly elevated (PTHrP 7.2 pmol/L, normal <1.1 pmol/L; MIP-1 alpha 84.9 pg/mL, normal <46.9 pg/mL). Her myeloma appeared to have simultaneously caused two mechanisms producing hypercalcemia: humoral hypercalcemia of malignancy (HHM) by PTHrP and local osteolytic hypercalcemia (LOH) by MIP-1 alpha. Therefore, the combination of two calcium-modulating abnormalities likely aggravated her hypercalcemia.

引用

页码：2993 / 2996

页数：4

共 19 条

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