Resurgent Na+ current: A new avenue to neuronal excitability control

被引：13

作者：

Cruz, Jader S. ^{[1
]}

Silva, Darizy F. ^{[2
]}

Ribeiro, Luciano A. ^{[2
]}

Araujo, Islania G. A. ^{[2
]}

Magalhaes, Nayara ^{[2
]}

Medeiros, Alessandra ^{[2
]}

Freitas, Christiane ^{[1
]}

Araujo, Izabella C. ^{[1
]}

Oliveira, Fernando A. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Inst Ciencias Biol, BR-31910901 Belo Horizonte, MG, Brazil

[2] Univ Fed Paraiba, Lab Tecnol Farmaceut, BR-58059900 Joao Pessoa, Paraiba, Brazil

来源：

LIFE SCIENCES | 2011年 / 89卷 / 15-16期

关键词：

Resurgent sodium current; Voltage-gated sodium channels; Neurons; CEREBELLAR PURKINJE NEURONS; VOLTAGE-GATED SODIUM; OPEN-CHANNEL BLOCK; FUNCTIONAL-ANALYSIS; BETA-SUBUNIT; K+ CHANNELS; ELECTROPHYSIOLOGICAL PROPERTIES; MOLECULAR-MECHANISMS; SENSORY NEURONS; IONIC CURRENTS;

D O I：

10.1016/j.lfs.2011.05.016

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Integrative and firing properties are important characteristics of neuronal circuits and these responses are determined in large part by the repertoire of ion channels they express, which can vary considerably between cell types. Recently, a new mode of operation of voltage dependent sodium channels has been described that generates a so-called resurgent Na+ current. Accumulating evidence suggests resurgent Na current participates in the generation of sub-threshold inward Na+ current causing membrane depolarization which provides the necessary drive to fire high-frequency action potentials. Recent studies indicate that resurgent Na+ current could be a more widespread feature than previously thought. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：564 / 569

页数：6

共 49 条

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