Host defense against malaria favors Salmonella

被引:6
|
作者
MacLennan, Calman A. [1 ]
机构
[1] Novartis Vaccines Inst Global Hlth, Siena, Italy
基金
英国医学研究理事会;
关键词
HEME OXYGENASE-1; INFECTIONS; PROTECTION; BACTEREMIA; CHILDREN; AFRICA; MICE;
D O I
10.1038/nm.2636
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The beneficial cytoprotective effects of heme oxygenase-1 (HO-1) in malaria infection are counterpoised by higher susceptibility to nontyphoidal Salmonella (NTS) bacteremia. A new study in mice co-infected with malaria and Salmonella provides a mechanism for the long-recognized association between malaria and NTS infection in African children. © 2012 Nature America, Inc. All rights reserved.
引用
收藏
页码:21 / 22
页数:2
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