Channel behavior in a gamma-aminobutyrate transporter

被引：89

作者：

Cammack, JN

Schwartz, EA

机构：

[1] Dept. Pharmacol. Physiological Sci., University of Chicago, Chicago, IL 60637

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 02期

关键词：

D O I：

10.1073/pnas.93.2.723

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian cell line was observed in cell-attached and excised membrane patches. When GABA was absent, a fraction of the transporters produced cation-permeable channels. When GABA plus Na+ was on either side of the membrane, the majority of transporters produced a high-frequency current noise attributed to the movement of ions In an occluded pore.

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页码：723 / 727

页数：5

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