Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

被引：557

作者：

Wang, Shutao ^{[1
,2
]}

Liu, Kan ^{[1
,3
]}

Liu, Jian ^{[1
,7
]}

Yu, Zeta T. -F. ^{[1
]}

Xu, Xiaowen ^{[1
]}

Zhao, Libo ^{[1
]}

Lee, Tom ^{[1
]}

Lee, Eun Kyung ^{[1
]}

Reiss, Jean ^{[4
]}

Lee, Yi-Kuen ^{[6
]}

Chung, Leland W. K. ^{[7
]}

Huang, Jiaoti ^{[4
]}

Rettig, Matthew ^{[5
]}

Seligson, David ^{[4
]}

Duraiswamy, Kumaran N. ^{[1
]}

Shen, Clifton K. -F. ^{[1
]}

Tseng, Hsian-Rong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Crump Inst Mol Imaging CIMI, Calif NanoSyst Inst CNSI,Inst Mol Med IMED, Los Angeles, CA 90095 USA

[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Beijing 100080, Peoples R China

[3] Wuhan Text Univ, Coll Elect & Informat Engn, Wuhan, Peoples R China

[4] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA 90095 USA

[6] Hong Kong Univ Sci & Technol, Dept Mech Engn, Hong Kong, Hong Kong, Peoples R China

[7] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Urooncol Res Program, Los Angeles, CA 90048 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 13期

关键词：

cancer diagnosis; cell capture; circulating tumor cell; microfluidics; nanostructured materials; CANCER METASTASIS; RARE CELLS; BLOOD; MICROFLUIDICS; PROGRESSION; EXPRESSION; GENES; EPCAM;

D O I：

10.1002/anie.201005853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibodycoated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression. (Figure Presented). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3084 / 3088

页数：5

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