Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

被引：549

作者：

Wang, Shutao ^{[1
,2
]}

Liu, Kan ^{[1
,3
]}

Liu, Jian ^{[1
,7
]}

Yu, Zeta T. -F. ^{[1
]}

Xu, Xiaowen ^{[1
]}

Zhao, Libo ^{[1
]}

Lee, Tom ^{[1
]}

Lee, Eun Kyung ^{[1
]}

Reiss, Jean ^{[4
]}

Lee, Yi-Kuen ^{[6
]}

Chung, Leland W. K. ^{[7
]}

Huang, Jiaoti ^{[4
]}

Rettig, Matthew ^{[5
]}

Seligson, David ^{[4
]}

Duraiswamy, Kumaran N. ^{[1
]}

Shen, Clifton K. -F. ^{[1
]}

Tseng, Hsian-Rong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Crump Inst Mol Imaging CIMI, Calif NanoSyst Inst CNSI,Inst Mol Med IMED, Los Angeles, CA 90095 USA

[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Beijing 100080, Peoples R China

[3] Wuhan Text Univ, Coll Elect & Informat Engn, Wuhan, Peoples R China

[4] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA 90095 USA

[6] Hong Kong Univ Sci & Technol, Dept Mech Engn, Hong Kong, Hong Kong, Peoples R China

[7] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Urooncol Res Program, Los Angeles, CA 90048 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 13期

关键词：

cancer diagnosis; cell capture; circulating tumor cell; microfluidics; nanostructured materials; CANCER METASTASIS; RARE CELLS; BLOOD; MICROFLUIDICS; PROGRESSION; EXPRESSION; GENES; EPCAM;

D O I：

10.1002/anie.201005853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibodycoated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression. (Figure Presented). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3084 / 3088

页数：5

共 50 条

[1] Capture of circulating tumor cells with a highly efficient nanostructured silicon substrates with integrated chaotic micromixers
Wang, Shutao
Liu, Kan
Liu, Jian
Yu, Zeta T. -F.
Xu, Xiaowen
Zhao, Libo
Lee, Tom
Lee, Eun Kyung
Reiss, Jean
Lee, Yi-Kuen
Chung, Leland W. K.
Huang, Jiaoti
Rettig, Matthew
Seligson, David
Duraiswamy, Kumaran N.
Shen, Clifton K. -F.
Tseng, Hsian-Rong
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2011, 40 : 235 - 235
[2] Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells
Wang, Shutao
Wang, Hao
Jiao, Jing
Chen, Kuan-Ju
Owens, Gwen E.
Kamei, Ken-ichiro
Sun, Jing
Sherman, David J.
Behrenbruch, Christian P.
Wu, Hong
Tseng, Hsian-Rong
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (47) : 8970 - 8973
[3] CAPTURE OF CIRCULATING PROSTATE TUMOR CELLS USING THREE-DIMENSIONAL SILICON NANOWIRE SUBSTRATES
Owens, G. E.
Wang, S.
Wang, H.
Jiao, J.
Chen, K.
Huang, J.
Pantuck, H.
Tseng, H.
JOURNAL OF INVESTIGATIVE MEDICINE, 2010, 58 (01) : 130 - 131
[4] Nanostructured substrates for isolation of circulating tumor cells
Wang, Lixue
Asghar, Waseem
Demirci, Utkan
Wan, Yuan
NANO TODAY, 2013, 8 (04) : 374 - 387
[5] Highly efficient capture and harvest of circulating tumor cells on a microfluidic chip integrated with herringbone and micropost arrays
Peng Xue
Yafeng Wu
Jinhong Guo
Yuejun Kang
Biomedical Microdevices, 2015, 17
[6] Integrated Multifunctional Electrochemistry Microchip for Highly Efficient Capture, Release, Lysis, and Analysis of Circulating Tumor Cells
Yan, Shuangqian
Chen, Peng
Zeng, Xuemei
Zhang, Xian
Li, Yiwei
Xia, Yun
Wang, Jie
Dai, Xiaofang
Feng, Xiaojun
Du, Wei
Liu, Bi-Feng
ANALYTICAL CHEMISTRY, 2017, 89 (22) : 12039 - 12044
[7] Highly efficient capture and harvest of circulating tumor cells on a microfluidic chip integrated with herringbone and micropost arrays
Xue, Peng
Wu, Yafeng
Guo, Jinhong
Kang, Yuejun
BIOMEDICAL MICRODEVICES, 2015, 17 (02)
[8] Highly efficient capture of circulating tumor cells with low background signals by using pyramidal microcavity array
Yin, Jiaxiang
Mou, Lei
Yang, Mingzhu
Zou, Wenwu
Du, Chang
Zhang, Wei
Jiang, Xingyu
ANALYTICA CHIMICA ACTA, 2019, 1060 : 133 - 141
[9] Construction of Nanostructured Inorganic Biointerface towards Highly Efficient Isolation of Circulating Tumor Cells
Liu Xue-Li
Wang Shu-Tao
CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2013, 29 (08) : 1609 - 1616
[10] Nanoroughened Surfaces for Efficient Capture of Circulating Tumor Cells without Using Capture Antibodies
Chen, Weiqiang
Weng, Shinuo
Zhang, Feng
Allen, Steven
Li, Xiang
Bao, Liwei
Lam, Raymond H. W.
Macoska, Jill A.
Merajver, Sofia D.
Fu, Jianping
ACS NANO, 2013, 7 (01) : 566 - 575

← 1 2 3 4 5 →