A central role for S-nitrosylation in apoptosis

被引：96

作者：

Benhar, M ^{[1
]}

Stamler, JS ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Howard Hughes Med Inst, Durham, NC 27710 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 07期

关键词：

D O I：

10.1038/ncb0705-645

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

New work reveals a key signal transduction pathway through which nitric oxide ( NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde- 3- phosphate dehydrogenase ( GAPDH) is S- nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin- mediated degradation of nuclear target proteins.

引用

页码：645 / 646

页数：2

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