Multicomponent Syntheses of Heterocycles Initiated by Catalytic Generation of Ynones and Ynediones

被引：32
作者：
Gers-Panthera, Charlotte F. [1 ,2 ]
Mueller, Thomas J. J. [1 ]
机构：
[1] Univ Dusseldorf, Inst Organ Chem & Makromol Chem, Univ Str 1, Dusseldorf, Germany
[2] Univ Oregon, Dept Chem & Biochem, Eugene, OR 97403 USA
来源：
HETEROCYCLIC CHEMISTRY IN THE 21ST CENTURY: A TRIBUTE TO ALAN KATRITZKY, VOL 120 | 2016年 / 120卷
关键词：
Alkynylation; Catalysis; Copper; Cross-coupling; Cycloaddition; Cyclocondensation; Heterocycles; Palladium; CONSECUTIVE 3-COMPONENT SYNTHESIS; ADDITION-CYCLOCONDENSATION SEQUENCE; COUPLING-FIESSELMANN SYNTHESIS; TETRAHYDRO-BETA-CARBOLINES; ONE-POT SYNTHESIS; 4-COMPONENT SYNTHESIS; TERMINAL ALKYNES; ACID-CHLORIDES; PYRIMIDINE SYNTHESIS; ORGANIC-SYNTHESIS;
D O I：
10.1016/bs.aihch.2016.04.007
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Propynones and 3-butyne-1,2-diones are densely substituted bi-and trifunctional electrophiles that can be generated by Pd-Cu-or by Cu-catalyzed alkynylation. The mild and general reaction conditions allow a straightforward entry to consecutive multicomponent syntheses of heterocycles conducted in a one-pot fashion. This overview presents recent advances in the catalytic generation of alkynones and alkynediones and their application to multicomponent syntheses of 19 classes of heterocycles in a diversity-oriented fashion.
引用
收藏
页码：67 / 98
页数：32
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