Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

被引：45

作者：

Ganesh, Mani ^{[1
,2
]}

Aziz, Abidov Sch ^{[1
]}

Ubaidulla, Udumansha ^{[3
]}

Hemalatha, Pushparaj ^{[4
]}

Saravanakumar, Arthanari ^{[1
]}

Ravikumar, Rramaswamy ^{[1
]}

Peng, Mei Mei ^{[1
]}

Choi, Eun Young ^{[5
]}

Jang, Hyun Tae ^{[1
]}

机构：

[1] Hanseo Univ, Dept Chem Engn, 360 Daegok Ri, Seosan 356706, Chungcheongnam, South Korea

[2] Hillside Coll Pharm, Bengaluru 560062, Karnataka, India

[3] CL Baid Metha Coll Pharm, Madras 600097, Tamil Nadu, India

[4] Anna Univ, Dept Chem, Madras 600025, Tamil Nadu, India

[5] Hanseo Univ, Dept Cosmetol, 360 Daegok Ri, Seosan 356706, Chungcheongnam, South Korea

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2016年 / 39卷

基金：

新加坡国家研究基金会;

关键词：

Nanofiber; Sulfanilamide; AgNP's; Wound healing; Antimicrobial; BIOSYNTHESIS; SPECTROSCOPY; MEMBRANES;

D O I：

10.1016/j.jiec.2016.05.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel silver nanoparticles-decorated chitosan (CS)-polyvinyl alcohol (PVA) composite electrospun nanofibers, loaded with sulfanilamide for enhanced wound healing have been developed. Herein, formic acid was used as a reducing agent to produce in situ colloidal silver nanoparticles (AgNPs) in the composite polymeric solution with the active agent sulfanilamide. The prepared electrospun fibers were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction, ultraviolet spectroscopy, and thermal gravimetric analysis (TG). Further, in vitro release, antimicrobial properties and in vivo wound healing activity were evaluated. The results revealed that the composite fibers displayed a synergistic antibacterial and wound healing activities. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：127 / 135

页数：9

共 53 条

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