The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review

被引:16
作者
Alhobayb, Tamara [1 ]
Peravali, Rahul [2 ]
Ashkar, Motaz [1 ]
机构
[1] Washington Univ, Sch Med, Div Gastroenterol, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
关键词
acute pancreatitis; chronic pancreatitis; pancreatic cancer; NF-KAPPA-B; PROCESSED MEAT CONSUMPTION; BODY-MASS INDEX; CANCER RISK; DIABETES-MELLITUS; TRANSCRIPTION FACTOR; CIGARETTE-SMOKING; POOLED ANALYSIS; STELLATE CELLS; INFLAMMATION;
D O I
10.3390/diseases9040093
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading to significant cancer-related mortality and an overall five-year survival rate of about nine percent. Acute and chronic pancreatitis have been associated with PDAC through common risk factors based on multiple epidemiological studies. Acute pancreatitis (AP) might be one of the earliest manifestations of PDAC, but evolving chronic pancreatitis (CP) following recurrent bouts of AP has been proposed as a risk factor for cancer development in the setting of persistent inflammation and ongoing exposure to carcinogens. This review aims to highlight the evidence supporting the relationship between acute and chronic pancreatitis with PDAC.
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页数:9
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