RETRACTED: Periodontitis and Cardiovascular Disease: Floss and Reduce a Potential Risk Factor for CVD (Retracted Article. See vol 62, pg 352, 2011)

被引：13

作者：

El Fadl, Khaled Abou ^{[1
]}

Ragy, Nivine ^{[1
]}

El Batran, Mona ^{[2
]}

Kassem, Neemat ^{[3
]}

Nasry, Sherine A. ^{[2
]}

Khalifa, Rania ^{[3
]}

Sedrak, Heba ^{[4
]}

Isenovic, Esma R. ^{[5
]}

机构：

[1] Cairo Univ, Dept Oral Med Periodontol & Diag, Fac Oral & Dent Med, Cairo, Egypt

[2] Natl Res Ctr, Dept Oral & Dent Med Res, Cairo, Egypt

[3] Cairo Univ, Dept Clin Pathol, Kasr Al Aini, Egypt

[4] Cairo Univ, Dept Internal Med, Kasr Al Aini, Egypt

[5] Univ Belgrade, Vinca Inst, Dept Mol Genet & Radiobiol, Belgrade, Serbia

来源：

ANGIOLOGY | 2011年 / 62卷 / 01期

关键词：

Periodontitis; cardiovascular disease; C-reactive protein; interleukin; 6; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; SYSTEMIC INFLAMMATION; INNOCENT BYSTANDER; ATHEROSCLEROSIS; INFECTIONS; INTERLEUKIN-6; MARKERS; METAANALYSIS; MORTALITY;

D O I：

10.1177/0003319710371617

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

There is evidence supporting an association between cardiovascular disease (CVD) and periodontitis. We determined whether patients with chronic periodontitis, who are otherwise healthy individuals, have higher serum concentrations of emerging risk markers of CVD such as C-reactive protein (CRP) and interleukin 6 (IL-6) and investigated the effect of subsequent periodontal treatment on the levels of these markers. A total of 40 individuals were included in the study. Serum levels of CRP and IL-6 were estimated twice, once on the initial visits and the other 3 months after periodontal therapy. The mean CRP and IL-6 levels were significantly higher (P < .001) in the patients compared with controls and significantly decreased (P < .001) following periodontal treatment. This study suggests that periodontitis is a potential modifiable risk factor for CVD.

引用

页码：62 / 67

页数：6

共 39 条

[11] Acute-phase reactants in infections and inflammatory diseases [J].

Ebersole, JL ;

Cappelli, D .

PERIODONTOLOGY 2000, 2000, 23 :19-49

[12]

HAKKE SK, 2002, CLIN PERIODONTOLOGY, P132

[13] Mechanisms of disease - Inflammation, atherosclerosis, and coronary artery disease [J].

Hansson, GK .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (16) :1685-1695

[14] Identification of periodontal pathogens in atheromatous plaques [J].

Haraszthy, VI ;

Zambon, JJ ;

Trevisan, M ;

Zeid, M ;

Genco, RJ .

JOURNAL OF PERIODONTOLOGY, 2000, 71 (10) :1554-1560

[15] Periodontitis-systemic disease associations in the presence of smoking - causal or coincidental? [J].

Hujoel, PP ;

Drangsholt, M ;

Spiekerman, C ;

DeRouen, TA .

PERIODONTOLOGY 2000, 2002, 30 :51-60

[16] Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses [J].

Ide, M ;

McPartlin, D ;

Coward, PY ;

Crook, M ;

Lumb, P ;

Wilson, RF .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2003, 30 (04) :334-340

[17] The short-term effects of treatment of chronic periodontitis on circulating levels of endotoxin, C-reactive protein, tumor necrosis factor-α, and interleukin-6 [J].

Ide, M ;

Jagdev, D ;

Coward, PY ;

Crook, M ;

Barclay, GR ;

Wilson, RF .

JOURNAL OF PERIODONTOLOGY, 2004, 75 (03) :420-428

[18] Effect of periodontal treatment on serum C-reactive protein levels: A systematic review and meta-analysis [J].

Ioannidou, Effie ;

Malekzadeh, Tannaz ;

Dongari-Bagtzoglou, Anna .

JOURNAL OF PERIODONTOLOGY, 2006, 77 (10) :1635-1642

[19] C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis [J].

Kaptoge, Stephen ;

Di Angelantonio, Emanuele ;

Lowe, Gordon ;

Pepys, Mark B. ;

Thompson, Simon G. ;

Collins, Rory ;

Danesh, John ;

Tipping, R. W. ;

Ford, C. E. ;

Pressel, S. L. ;

Walldius, G. ;

Jungner, I. ;

Folsom, A. R. ;

Chambless, L. ;

Ballantyne, C. M. ;

Panagiotakos, D. ;

Pitsavos, C. ;

Chrysohoou, C. ;

Stefanadis, C. ;

Knuiman, M. W. ;

Goldbourt, U. ;

Benderly, M. ;

Tanne, D. ;

Whincup, P. ;

Wannamethee, S. G. ;

Morris, R. W. ;

Kiechl, S. ;

Willeit, J. ;

Mayr, A. ;

Schett, G. ;

Wald, N. ;

Ebrahim, S. ;

Lawlor, D. ;

Yarnell, J. ;

Gallacher, J. ;

Casiglia, E. ;

Tikhonoff, V. ;

Nietert, P. J. ;

Sutherland, S. E. ;

Bachman, D. L. ;

Keil, J. E. ;

Cushman, M. ;

Psaty, B. M. ;

Tracy, R. ;

Tybjaerg-Hansen, A. ;

Nordestgaard, B. G. ;

Zacho, J. ;

Frikke-Schmidt, R. ;

Giampaoli, S. ;

Palmieri, L. .

LANCET, 2010, 375 (9709) :132-140

[20] C-reactive protein as a cardiovascular risk factor - More than an epiphenomenon? [J].

Lagrand, WK ;

Visser, CA ;

Hermens, WT ;

Niessen, HWM ;

Verheugt, FWA ;

Wolbink, GJ ;

Hack, CE .

CIRCULATION, 1999, 100 (01) :96-102

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