A Review of Gum Hydrocolloid Polyelectrolyte Complexes (PEC) for Biomedical Applications: Their Properties and Drug Delivery Studies

被引：14

作者：

Putro, Jindrayani Nyoo ^{[1
]}

Lunardi, Valentino Bervia ^{[1
]}

Soetaredjo, Felycia Edi ^{[1
]}

Yuliana, Maria ^{[1
]}

Santoso, Shella Permatasari ^{[1
]}

Wenten, I. Gede ^{[2
,3
]}

Ismadji, Suryadi ^{[1
]}

机构：

[1] Widya Mandala Surabaya Catholic Univ, Dept Chem Engn, Kalijudan 37, Surabaya 60114, Indonesia

[2] Inst Teknol Bandung, Chem Engn Dept, Jalan Ganesa 10, Bandung 40132, Indonesia

[3] Inst Teknol Bandung, Res Ctr Nanosci & Nanotechnol, Jalan Ganesa 10, Bandung 40132, Indonesia

来源：

PROCESSES | 2021年 / 9卷 / 10期

关键词：

gum polysaccharides; drug delivery; polyelectrolyte complexes; hydrocolloid; GELLAN GUM; CONTROLLED-RELEASE; SOLUTE RELEASE; GUAR GUM; CHITOSAN; PH; NANOPARTICLES; MECHANISMS; BEHAVIOR; TABLETS;

D O I：

10.3390/pr9101796

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, and price are much cheaper than other materials. It is also renewable and available in massive amounts, which are the main reasons for its use in pharmaceutical applications. Gum can be easily functionalized with other natural polymers to enhance their applications. Various aspects of the utilization of natural gums in the forms of polyelectrolyte complexes (PECs) for drug delivery systems are discussed in this review. The application of different mathematical models were used to represent the drug release mechanisms from PECs; these models include a zero-order equation, first-order equation, Higuchi, simplified Higuchi, Korsmeyer-Peppas, and Peppas-Sahlin.

引用

页数：29

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