Management of leptomeningeal carcinomatosis and challenges of trial design

被引：9

作者：

Gill, Corey M. ^{[1
]}

Brastianos, Priscilla K. ^{[2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[2] Massachusetts Gen Hosp, 55 Fruit St,Yawkey 9E, Boston, MA 02114 USA

[3] Harvard Med Sch, 55 Fruit St,Yawkey 9E, Boston, MA 02114 USA

来源：

CURRENT OPINION IN ONCOLOGY | 2019年 / 31卷 / 06期

关键词：

breast cancer; clinical trial; leptomeningeal; lung cancer; meningeal carcinomatosis; CELL LUNG-CANCER; PROGNOSTIC-FACTORS; METASTASIS; SURVIVAL;

D O I：

10.1097/CCO.0000000000000574

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of review Highlight recent data in lung and breast cancer leptomeningeal disease and address clinical trials that are open for patients. Recent findings Patients with lung and breast cancer leptomeningeal disease have survival outcomes of less than 1 year, despite advances in treatment strategy. Efforts to develop liquid biopsy biomarkers of disease progression from cerebrospinal fluid and plasma are underway. There are over 10 clinical trials open for patients with leptomeningeal disease, half of which use immunotherapy. Consortium-based, multicenter clinical trials for patients with leptomeningeal disease are urgently needed to expand the treatment armamentarium.

引用

页码：508 / 513

页数：6

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