CXCL12 and CXCR4 in bone marrow physiology

被引：73

作者：

Moll, Natalia M. ^{[1
]}

Ransohoff, Richard M. ^{[2
]}

机构：

[1] UPMC, Hop Pitie Salpetriere, Fac Med Pierre & Marie Curie, CNRS,CRICM,INSERM,UMRS 975,UMR 7225, F-75634 Paris, France

[2] Lerner Res Inst, Cleveland Clin, Cleveland, OH 44195 USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2010年 / 3卷 / 03期

关键词：

bone marrow; chemokine; CXCL12; CXCR4; CXCR7; stem cell; HEMATOPOIETIC-STEM-CELL; CHEMOKINE RECEPTOR CXCR4; HOMING-RELATED RESPONSES; PROGENITOR CELLS; STEM/PROGENITOR CELLS; CD34(+) CELLS; FACTOR-I; LYMPHOCYTE CHEMOATTRACTANT; SULFATED POLYSACCHARIDES; NERVOUS-SYSTEM;

D O I：

10.1586/EHM.10.16

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis. The selective signaling pathways that mediate these varied outcomes are summarized briefly. The CXCL12/CXCR4 pair is crucially involved in homing and repopulation of HSCs in the specific BM niches. Mechanisms of HSC mobilization to the peripheral circulation in response to physiological requests and therapeutic stimulations, as well as recent data on the novel receptor for CXCL12, CXCR7, are reviewed.

引用

页码：315 / 322

页数：8

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