SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 2-ACETYL-5-HYDROXY-5-METHYL-3-PHENYL-1-CYCLOHEXANONE AND ALKYL-4-HYDROXY-4-METHYL-2-OXO-6-PHENYLCYCLOHEXANE-1-CARBOXYLATES

被引：12

作者：

Gein, V. L. ^{[1
]}

Vagapov, A. V. ^{[1
]}

Nosova, N. V. ^{[1
]}

Voronina, E. V. ^{[1
]}

Vakhrin, M. I. ^{[1
]}

Kriven'ko, A. P. ^{[2
]}

机构：

[1] Perm State Pharmaceut Acad, Perm 614990, Russia

[2] Saratov NG Chernyshevskii State Univ, Saratov, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 05期

关键词：

cyclohexanone; cyclohexanecarboxylates; antimicrobial activity; beta-cycloketoles; alkyl-2-oxocyclohexanecarboxylates;

D O I：

10.1007/s11094-010-0440-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-acetyl-5-hydroxy-5-methyl-3-phenyl-1-cyclohexanone and alkyl-4-hydroxy-4-methyl-2-oxo-6-phenylcyclohexane-1-carboxylates have been obtained via interaction of benzalacetone with various acetoacetates and acetylacetone in an ethanol solution of potassium hydroxide. The antimicrobial activity of the synthesized compounds has been studied.

引用

页码：245 / 247

页数：3