Cellular microparticles and pathophysiology of traumatic brain injury

被引：38

作者：

Zhao, Zilong ^{[1
,2
]}

Zhou, Yuan ^{[1
,2
]}

Tian, Ye ^{[1
]}

Li, Min ^{[3
]}

Dong, Jing-fei ^{[2
,4
]}

Zhang, Jianning ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Inst Neurol, Dept Neurosurg, Gen Hosp, Tianjin 300052, Peoples R China

[2] BloodWorks Northwest Res Inst, Seattle, WA 98102 USA

[3] Lanzhou Univ, Inst Pathol, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China

[4] Univ Washington, Sch Med, Dept Med, Div Hematol, Seattle, WA 98195 USA

来源：

PROTEIN & CELL | 2017年 / 8卷 / 11期

基金：

中国国家自然科学基金;

关键词：

traumatic brain injury; cellular microparticles; coagulopathy; inflammation; MITOCHONDRIAL OUTER-MEMBRANE; RED-BLOOD-CELLS; CEREBROSPINAL-FLUID; TISSUE-FACTOR; INTRAVASCULAR COAGULATION; EXTRACELLULAR VESICLES; PROCOAGULANT ACTIVITY; OXIDATIVE LIPIDOMICS; THERAPEUTIC TARGET; POLYMORPHONUCLEAR NEUTROPHILS;

D O I：

10.1007/s13238-017-0414-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The finding that cellular microparticles (MPs) generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.

引用

页码：801 / 810

页数：10

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