Chromo-domain proteins: linking chromatin structure to epigenetic regulation

被引：150

作者：

Cavalli, G ^{[1
]}

Paro, R ^{[1
]}

机构：

[1] Univ Heidelberg, Zentrum Mol Biol, D-62120 Heidelberg, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(98)80011-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromo-domain proteins appear to be a central component in the epigenetic regulation of heterochromatin function and euchromatic gene expression. The recent discovery of a variety of interacting partners of chrome-domain proteins is yielding new molecular insights into epigenetic regulatory processes acting at the level of higher order chromatin structure.

引用

页码：354 / 360

页数：7

共 37 条

[1]

AASLAND R, 1995, NUCLEIC ACIDS RES, V23, P3163

[2] Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex [J].

Alkema, MJ ;

Bronk, M ;

Verhoeven, E ;

Otte, A ;

vantVeer, LT ;

Berns, A ;

vanLohuizen, M .

GENES & DEVELOPMENT, 1997, 11 (02) :226-240

[3]

ALLSHIRE RC, 1996, EPIGENETIC MECH GENE, P443

[4] Structure of the chromatin binding (chromo) domain from mouse modifier protein 1 [J].

Ball, LJ ;

Murzina, NV ;

Broadhurst, RW ;

Raine, ARC ;

Archer, SJ ;

Stott, FJ ;

Murzin, AG ;

Singh, PB ;

Domaille, PJ ;

Laue, ED .

EMBO JOURNAL, 1997, 16 (09) :2473-2481

[5] Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin [J].

Brown, KE ;

Guest, SS ;

Smale, ST ;

Hahm, K ;

Merkenschlager, M ;

Fisher, AG .

CELL, 1997, 91 (06) :845-854

[6] SILENCERS IN ABDOMINAL-B, A HOMEOTIC DROSOPHILA GENE [J].

BUSTURIA, A ;

BIENZ, M .

EMBO JOURNAL, 1993, 12 (04) :1415-1425

[7] Hydrophobic cluster analysis reveals a third chromodomain in the Tetrahymena Pdd1p protein of the chromo superfamily [J].

Callebaut, I ;

Courvalin, JC ;

Worman, KJ ;

Mornon, JP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (01) :103-107

[8] The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis [J].

Cavalli, G ;

Paro, R .

CELL, 1998, 93 (04) :505-518

[9] A POLYCOMB RESPONSE ELEMENT IN THE UBX GENE THAT DETERMINES AN EPIGENETICALLY INHERITED STATE OF REPRESSION [J].

CHAN, CS ;

RASTELLI, L ;

PIRROTTA, V .

EMBO JOURNAL, 1994, 13 (11) :2553-2564

[10] SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation [J].

Cleard, F ;

Delattre, M ;

Spierer, P .

EMBO JOURNAL, 1997, 16 (17) :5280-5288

← 1 2 3 4 →