Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis

被引：146

作者：

Gorter, Jan A. ^{[1
]}

van Vliet, Erwin A. ^{[2
]}

Aronica, Eleonora ^{[1
,2
,3
]}

机构：

[1] Univ Amsterdam, Swammerdam Inst Life Sci, Ctr Neurosci, Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Neuro Pathol, NL-1105 AZ Amsterdam, Netherlands

[3] SEIN, Heemstede, Netherlands

来源：

EPILEPSY & BEHAVIOR | 2015年 / 49卷

关键词：

Status epilepticus; Blood-brain barrier; Leakage; Inflammation; Angiogenesis; Immune response; Epilepsy; TEMPORAL-LOBE EPILEPSY; ACID-INDUCED SEIZURES; MAMMALIAN TARGET; ACQUIRED EPILEPSY; RAT HIPPOCAMPUS; IRON INJECTION; IN-VIVO; MODEL; RAPAMYCIN; PATHOPHYSIOLOGY;

D O I：

10.1016/j.yebeh.2015.04.047

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：13 / 16

页数：4

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