Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis

被引：145

作者：

Gorter, Jan A. ^{[1
]}

van Vliet, Erwin A. ^{[2
]}

Aronica, Eleonora ^{[1
,2
,3
]}

机构：

[1] Univ Amsterdam, Swammerdam Inst Life Sci, Ctr Neurosci, Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Neuro Pathol, NL-1105 AZ Amsterdam, Netherlands

[3] SEIN, Heemstede, Netherlands

来源：

EPILEPSY & BEHAVIOR | 2015年 / 49卷

关键词：

Status epilepticus; Blood-brain barrier; Leakage; Inflammation; Angiogenesis; Immune response; Epilepsy; TEMPORAL-LOBE EPILEPSY; ACID-INDUCED SEIZURES; MAMMALIAN TARGET; ACQUIRED EPILEPSY; RAT HIPPOCAMPUS; IRON INJECTION; IN-VIVO; MODEL; RAPAMYCIN; PATHOPHYSIOLOGY;

D O I：

10.1016/j.yebeh.2015.04.047

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：13 / 16

页数：4

共 68 条

[1] Overview and introduction: The blood-brain barrier in health and disease [J].

Abbott, N. Joan ;

Friedman, Alon .

EPILEPSIA, 2012, 53 :1-6

[2] Astrocyte-endothelial interactions at the blood-brain barrier [J].

Abbott, NJ ;

Rönnbäck, L ;

Hansson, E .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53

[3] Losartan Prevents Acquired Epilepsy via TGF-β Signaling Suppression [J].

Bar-Klein, Guy ;

Cacheaux, Luisa P. ;

Kamintsky, Lyn ;

Prager, Ofer ;

Weissberg, Itai ;

Schoknecht, Karl ;

Cheng, Paul ;

Kim, Soo Young ;

Wood, Lydia ;

Heinemann, Uwe ;

Kaufer, Daniela ;

Friedman, Alon .

ANNALS OF NEUROLOGY, 2014, 75 (06) :864-875

[4] Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy [J].

Buckmaster, Paul S. ;

Lew, Felicia H. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (06) :2337-2347

[5] Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis [J].

Cacheaux, Luisa P. ;

Ivens, Sebastian ;

David, Yaron ;

Lakhter, Alexander J. ;

Bar-Klein, Guy ;

Shapira, Michael ;

Heinemann, Uwe ;

Friedman, Alon ;

Kaufer, Daniela .

JOURNAL OF NEUROSCIENCE, 2009, 29 (28) :8927-8935

[6] Status epilepticus: pathophysiology and management in adults [J].

Chen, JWY ;

Wasterlain, CG .

LANCET NEUROLOGY, 2006, 5 (03) :246-256

[7] Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier [J].

Cornford, EM ;

Hyman, S ;

Cornford, ME ;

Landaw, EM ;

Delgado-Escueta, AV .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1998, 18 (01) :26-42

[8] VEGF-mediated inflammation precedes angiogenesis in adult brain [J].

Croll, SD ;

Ransohoff, RM ;

Cai, N ;

Zhang, Q ;

Martin, FJ ;

Wei, T ;

Kasselman, LJ ;

Kintner, J ;

Murphy, AJ ;

Yancopoulos, GD ;

Wiegand, SJ .

EXPERIMENTAL NEUROLOGY, 2004, 187 (02) :388-402

[9] Glia and epilepsy: excitability and inflammation [J].

Devinsky, Orrin ;

Vezzani, Annamaria ;

Najjar, Souhel ;

De Lanerolle, Nihal C. ;

Rogawski, Michael A. .

TRENDS IN NEUROSCIENCES, 2013, 36 (03) :174-184

[10] Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent [J].

Duffy, Ben A. ;

Choy, ManKin ;

Riegler, Johannes ;

Wells, Jack A. ;

Anthony, Daniel C. ;

Scott, Rod C. ;

Lythgoe, Mark F. .

NEUROIMAGE, 2012, 60 (02) :1149-1155

← 1 2 3 4 5 6 7 →