Electrochemical Amidation: Benzoyl Hydrazine/Carbazate and Amine as Coupling Partners

被引：22

作者：

Alam, Tipu ^{[1
]}

Rakshit, Amitava ^{[1
]}

Dhara, Hirendra Nath ^{[1
]}

Palai, Angshuman ^{[1
]}

Patel, Bhisma K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, North Guwahati 781039, India

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 36期

关键词：

BOND FORMATION; ACYL; AMIDES; ACIDS;

D O I：

10.1021/acs.orglett.2c02626

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine as coupling partners via concomitant cleavage and formation of C(sp(2))-N bonds has been achieved. This methodology proceeds under metal- free and exogenous oxidant-free conditions producing N-2 and H-2 as byproducts. Mechanistic studies reveal the in situ generations of both acyl and N-centered radicals from benzoyl hydrazines and amines. The utility of this protocol is demonstrated through a large-scale, and synthesis of bezafibrate, a hyperlipidemic drug.

引用

页码：6619 / 6624

页数：6

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