Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes

被引：71

作者：

Wang, Liangguang ^{[1
]}

Yu, Xiaoqiang ^{[1
]}

Feng, Xiujuan ^{[1
]}

Bao, Ming ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; ALKYNYL OXIME ETHERS; COPPER(I)-CATALYZED SYNTHESIS; ELECTROPHILIC CYCLIZATION; REGIOSELECTIVE SYNTHESIS; N-OXIDES; EFFICIENT; CYCLOADDITION; DERIVATIVES; CONVENIENT;

D O I：

10.1021/ol300872e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of 3,5-disubstituted Isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles In satisfactory to excellent yields.

引用

页码：2418 / 2421

页数：4

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