Targeting Cancer Stem Cells to Overcome Chemoresistance

被引：114

作者：

Nunes, Toni ^{[1
,2
]}

Hamdan, Diaddin ^{[1
,3
]}

Leboeuf, Christophe ^{[1
,2
]}

El Bouchtaoui, Morad ^{[1
,2
]}

Gapihan, Guillaume ^{[1
,2
]}

Thi Thuy Nguyen ^{[1
]}

Meles, Solveig ^{[1
]}

Angeli, Eurydice ^{[1
]}

Ratajczak, Philippe ^{[1
,2
]}

Lu, He ^{[1
,2
]}

Di Benedetto, Melanie ^{[1
,2
,4
]}

Bousquet, Guilhem ^{[1
,2
,4
,5
]}

Janin, Anne ^{[1
,2
,6
]}

机构：

[1] INSERM, U1165, F-75010 Paris, France

[2] Univ Paris Diderot, Sorbonne Paris Cite, Pathol Lab, UMR S1165, F-75010 Paris, France

[3] Hop La Porte Verte, F-78004 Versailles, France

[4] Univ Paris 13, F-93430 Villetaneuse, France

[5] Hop Avicenne, AP HP, Med Oncol Serv, F-93008 Bobigny, France

[6] Hop St Louis, AP HP, Serv Pathol, F-75010 Paris, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期

关键词：

cancer; chemoresistance; cancer stem cell; gold nanoparticles; functionalization; photo-thermal therapy; PLASMONIC PHOTOTHERMAL THERAPY; ANTI-ENDOGLIN ANTIBODY; TUMOR-INITIATING CELLS; NEGATIVE BREAST-CANCER; OVARIAN-CANCER; IN-VITRO; ALDEHYDE DEHYDROGENASE; GOLD NANOPARTICLES; SIDE POPULATION; SELF-RENEWAL;

D O I：

10.3390/ijms19124036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem cell surface markers. Gold nanoparticles have emerged as innovative tools, particularly for photo-thermal therapy since they can be excited by laser to induce hyperthermia. Gold nanoparticles can be functionalized with antibodies to specifically target cancer stem cells. Preclinical studies using photo-thermal therapy have demonstrated the feasibility of targeting chemo-resistant cancer cells to reverse clinical chemoresistance. Here, we review the data linking cancer stem cells and chemoresistance and discuss the way to target them to reverse resistance. We particularly focus on the use of functionalized gold nanoparticles in the treatment of chemo-resistant metastatic cancers.

引用

页数：24

共 245 条

[1] The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer [J].