CuI/PPh3/PEG-WATER: AN EFFICIENT CATALYTIC SYSTEM FOR CROSS-COUPLING REACTION OF ARYL IODIDES AND ALKYNES

被引：16

作者：

Chen, Gong ^{[1
]}

Xie, Jianwei ^{[1
]}

Weng, Jiang ^{[1
]}

Zhu, Xinhai ^{[1
]}

Zheng, Zhanchao ^{[1
]}

Cai, Jiwen ^{[1
]}

Wan, Yiqian ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 21期

基金：

国家高技术研究发展计划(863计划);

关键词：

Alkynation; aqueous chemistry; copper; coupling; microwave-assisted chemistry; FREE SONOGASHIRA REACTION; COPPER-FREE; AMINE-FREE; LIGAND-FREE; POLY(ETHYLENE GLYCOL); TERMINAL ACETYLENES; PALLADIUM CATALYST; HALIDES; WATER; CARBON;

D O I：

10.1080/00397911.2010.517363

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol for the copper-catalyzed Sonogashira coupling of aryl iodides with terminal acetylenes in water-polyethylene glycol has been established. Both electron-rich and electron-deficient aryl iodides were arylalkynated under microwave heating or reflux in oil bath to afford good to excellent yields.

引用

页码：3123 / 3133

页数：11

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