Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of Pt

被引：14

作者：

Behmand, B. ^{[1
]}

Marignier, J. -L. ^{[2
]}

Mostafavi, M. ^{[2
]}

Wagner, J. R. ^{[1
]}

Hunting, D. J. ^{[1
]}

Sanche, L. ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Med & Sci Sante, Grp Sci Radiat, Sherbrooke, PQ J1H 5N4, Canada

[2] Univ Paris 11, Ctr Cinet Rapide ELYSE, Lab Chim Phys, F-91405 Orsay, France

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2015年 / 119卷 / 30期

关键词：

DOUBLE-STRAND BREAKS; PULSE-RADIOLYSIS; RADIATION-THERAPY; CELLS; CHEMOTHERAPY; CANCER; DAMAGE; PRESERVATION; RECOGNITION; ACCELERATOR;

D O I：

10.1021/acs.jpcb.5b01752

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Pulse radiolysis measurements of the decay of hydrated.. electrons in solutions containing different concentrations of the oligonucleotide GTG with and without a cisplatin adduct show that the presence of a cisplatin moiety accelerates the reaction between hydrated: electrons and the oligonucleotide: The rate constant of the reaction is foond to be 2.23 x 10(10) mol(-1) L s(-1), which indicates that it is diffusion. controlled. In addition, we show for the first time the formation of a Pt-I intermediate as a result of the reaction of hydrated elections With GTG-cisplatin. A putative reaction mechanism is proposed, Which limy form the basis of the radiosensititation of cancer cells in concomitant chemoratiation therapy with cisplatin.

引用

页码：9496 / 9500

页数：5

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