Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of Pt

被引：14
作者：
Behmand, B. [1 ]
Marignier, J. -L. [2 ]
Mostafavi, M. [2 ]
Wagner, J. R. [1 ]
Hunting, D. J. [1 ]
Sanche, L. [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Sci Sante, Grp Sci Radiat, Sherbrooke, PQ J1H 5N4, Canada
[2] Univ Paris 11, Ctr Cinet Rapide ELYSE, Lab Chim Phys, F-91405 Orsay, France
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 2015年 / 119卷 / 30期
关键词：
DOUBLE-STRAND BREAKS; PULSE-RADIOLYSIS; RADIATION-THERAPY; CELLS; CHEMOTHERAPY; CANCER; DAMAGE; PRESERVATION; RECOGNITION; ACCELERATOR;
D O I：
10.1021/acs.jpcb.5b01752
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Pulse radiolysis measurements of the decay of hydrated.. electrons in solutions containing different concentrations of the oligonucleotide GTG with and without a cisplatin adduct show that the presence of a cisplatin moiety accelerates the reaction between hydrated: electrons and the oligonucleotide: The rate constant of the reaction is foond to be 2.23 x 10(10) mol(-1) L s(-1), which indicates that it is diffusion. controlled. In addition, we show for the first time the formation of a Pt-I intermediate as a result of the reaction of hydrated elections With GTG-cisplatin. A putative reaction mechanism is proposed, Which limy form the basis of the radiosensititation of cancer cells in concomitant chemoratiation therapy with cisplatin.
引用
收藏
页码：9496 / 9500
页数：5
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