Rhodium(III)-Catalyzed [4+3] Annulation of N-Aryl-pyrazolidinones and Propargylic Acetates: Access to Benzo[c][1,2]diazepines

被引：44

作者：

Li, Tingfang ^{[1
]}

Yang, Zi ^{[1
]}

Song, Zhenyu ^{[1
]}

Chauvin, Remi ^{[1
,2
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huagiao Univ, Key Lab Precis Med & Mol Diag Fujian Univ, Key Lab Xiamen Marine & Gene Drugs,Sch Biomed Sci, Engn Res Ctr Mol Med,Minist Educ,Key Lab Fujian M, Xiamen 361021, Peoples R China

[2] Univ Toulouse, LCC CNRS, UPS, F-31077 Toulouse, France

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 11期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; FORMAL 3+2+2 CYCLOADDITION; AZOMETHINE IMINES; NITROGEN-HETEROCYCLES; MEDIATED SYNTHESIS; FUNCTIONALIZATION; CYCLIZATION; PHENIDONES; AZIRIDINES; AZOALKENES;

D O I：

10.1021/acs.orglett.0c01139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The generation of 2,3-dihydro-benzo[c][1,2]-diazepine derivatives via rhodium(III)-catalyzed [4+3] annulation of pyrazolidinones and propargylic acetates is disclosed. The reaction proceeds smoothly under relatively mild conditions from propargylic acetates as novel C3 synthons. A range of dinitrogen-fused heterocyclic compounds are readily accessed by this approach.

引用

页码：4078 / 4082

页数：5

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