Neurofilament protein levels in CSF are increased in dementia

被引：124
|
作者：
Rosengren, LE [1 ]
Karlsson, JE
Sjögren, M
Blennow, K
Wallin, A
机构：
[1] Gothenburg Univ, Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Neurol, S-41345 Gothenburg, Sweden
[2] Gothenburg Univ, Sahlgrens Univ Hosp, Dept Neurochem, Gothenburg, Sweden
[3] Gothenburg Univ, Sahlgrens Univ Hosp, Dept Psychiat, Gothenburg, Sweden
来源：
NEUROLOGY | 1999年 / 52卷 / 05期
关键词：
D O I：
10.1212/WNL.52.5.1090
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light; subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.
引用
收藏
页码：1090 / 1093
页数：4
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