Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease

被引:190
作者
Lisman, Ton [1 ,2 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Surg Res Lab, BA33,Hanzepl 1, NL-9713 GZ Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Sect Hepatobiliary Surg & Liver Transplantat, BA33,Hanzepl 1, NL-9713 GZ Groningen, Netherlands
关键词
Platelet; Neutrophil; Inflammation; Thrombosis; Ischemia; VON-WILLEBRAND-FACTOR; ISCHEMIA-REPERFUSION INJURY; PROTEASE-ACTIVATED RECEPTOR-4; EXTRACELLULAR TRAP FORMATION; TISSUE FACTOR EXPRESSION; IMPAIRS HOST-DEFENSE; DEEP-VEIN THROMBOSIS; INDUCED LIVER-INJURY; P-SELECTIN; CATHEPSIN-G;
D O I
10.1007/s00441-017-2727-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.
引用
收藏
页码:567 / 576
页数:10
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