A Novel Synthesis of Isoflavones via Copper(I)-Catalyzed Intramolecular Cyclization Reaction

被引：14

作者：

Li, Qiu-Lian ^{[1
]}

Liu, Qi-Lun ^{[1
]}

Ge, Zhi-Yuan ^{[1
]}

Zhu, Yong-Ming ^{[1
]}

机构：

[1] Soochow Univ, Sch Pharm, Suzhou 215123, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2011年 / 94卷 / 07期

关键词：

AMINATION REACTION;

D O I：

10.1002/hlca.201000400

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Isoflavone derivatives were synthesized via intramolecular cyclization of 3-(2-bromophenyl)-3-oxopropanal derivatives, using CuI as the catalyst, 2-picolinic acid (= pyridine-2-carboxylic acid) as the ligand, K(2)CO(3) as the base, and DMF as the solvent, in up to 96% yield. The synthesis is functional group-tolerant.

引用

页码：1304 / 1309

页数：6

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