Invitro evaluations of free radical assisted microwave irradiated polyacrylamide grafted cashew gum (CG) biocompatible graft copolymer (CG-g-PAM) as effective polymeric scaffold

The study is mainly focused on the synthesis of polyacrylamide grafted cashew gum (CG-g-PAM) biocompatible graft copolymer as polymeric scaffold for tissue growth by free radical assisted microwave irradiation method using varying quantities of redox initiator ammonium persulfate (APS) for synthesis of CG-g-PAM graft copolymer and final copolymer was precipitated in presence of excess of acetone to remove the homopolymer and other unreacted monomer and byproducts. Percentage grafting efficiency (%GE) was selected as the optimization parameter for best grade. Various analytical techniques like fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and thermogravimetric analysis (TGA) studies were utilized for analyzing optimized grade GFS-3 The inserted grade GFS-3 in mice model showed satisfactory tissue growth over it ensuring biocompatibility along with evidences of nontoxicity on local tissue as well as on major organs like liver and kidney upon oral administration respectively. Moreover, GFS-3 was found to be hemocompatible in presence of mice blood.