Intermuscular Adipose Tissue and Subclinical Coronary Artery Calcification in Midlife The CARDIA Study (Coronary Artery Risk Development in Young Adults)

被引:51
作者
Terry, James G. [1 ]
Shay, Christina M. [2 ]
Schreiner, Pamela J. [3 ]
Jacobs, David R., Jr. [3 ]
Sanchez, Otto A. [4 ,5 ]
Reis, Jared P. [6 ]
Goff, David C., Jr. [6 ]
Gidding, Samuel S. [7 ]
Steffen, Lyn M. [3 ]
Carr, John Jeffrey [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Radiol, Nashville, TN 37203 USA
[2] Amer Heart Assoc, Dallas, TX USA
[3] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA
[4] Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA
[5] Dept Internal Med, Bethesda, MD USA
[6] NIH, Bldg 10, Bethesda, MD 20892 USA
[7] Alfred I DuPont Hosp Children, Wilmington, DE USA
关键词
adipose tissue; body mass index; muscle; prevalence; risk factors; vascular calcification; MONOCYTE CHEMOATTRACTANT PROTEIN-1; FATTY LIVER-DISEASE; HEART-DISEASE; BODY-COMPOSITION; INSULIN-RESISTANCE; ABDOMINAL OBESITY; PERICARDIAL FAT; VISCERAL FAT; ECTOPIC FAT; ATHEROSCLEROSIS;
D O I
10.1161/ATVBAHA.117.309633
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-Excess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants. Approach and Results-We measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models. Conclusions-In a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots. Visual Overview-An online visual overview is available for this article.
引用
收藏
页码:2370 / +
页数:18
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