The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia

被引:10
作者
Cui, Zhanhu [1 ,2 ]
Li, Siqi [3 ]
Chang, Jiayin [3 ]
Zang, Erhuan [3 ]
Liu, Qian [3 ]
Zhou, Baochang [4 ]
Li, Chao [5 ]
Li, Mengzhi [5 ]
Huang, Xianzhang [5 ]
Zhang, Zhongyi [1 ]
Li, Minhui [3 ,4 ,6 ]
机构
[1] Fujian Agr & Forestry Univ, Coll Agr, Fuzhou, Peoples R China
[2] Henan Univ, Peoples Hosp 1, Nanyang Affiliated, Nanyang, Peoples R China
[3] Baotou Med Coll, Inner Mongolia Key Lab Characterist Geoherbs Resou, Baotou, Peoples R China
[4] Inner Mongolia Med Univ, Coll Tradit Chinese Med, Hohhot, Peoples R China
[5] Nanyang Inst Technol, Nanyang, Peoples R China
[6] Inner Mongolia Hosp Tradit Chinese Med, Hohhot, Peoples R China
基金
中国国家自然科学基金;
关键词
Artemisia argyi; Artemisia indica; pharmaphylogeny; metabolomics; network pharmacology; inflammation; INFLAMMATORY RESPONSES; MACROPHAGES; LPS;
D O I
10.3389/fpls.2022.949743
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Artemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica in China and a phylogenetic tree of common medicinal plants in Asteraceae. Then, we verified the chemical composition changes of A. argyi and A. indica via their metabolome. Traditional efficacy and modern pharmacological action were verified by network pharmacology and in vitro using RAW264.7 cells. The results showed that A. argyi and A. indica are widely distributed in China, and they shared pharmaphylogeny, which provides theoretical support for the mixed use of A. argyi and A. indica in most regions of China. Furthermore, there were both similarities and differences in volatile oil and flavonoid composition between A. argyi and A. indica. The network pharmacology results showed that A. argyi and A. indica had 23 common active compounds and that both had pharmacological effects on chronic gastritis (CG). Molecular docking analyses showed that quercetin, luteolin, and kaempferol have strong binding affinities with the target proteins JUN, TP53, AKT1, MAPK3, TNF, MAPK, and IL6. The cell experiment results further demonstrated that A. argyi and A. indica treat CG via the NOD-like receptor pathway. Based on the theory of pharmaphylogeny, this study explored the pharmaphylogeny between A. argyi and A. indica from various perspectives to provide a basis for the substitution of A. argyi and A. indica.
引用
收藏
页数:16
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